PUBLICATIONS
Legend
* Authors contributed equally
Underlined authors are trainees from the Bruin Lab
2024
Ewald JD, Lu Y, Ellis CE, Worton J, Kolic J, Sasaki S, Zhang D, Santos T, Spigelman AF, Bautista A, Dai X, Lyon JG, Smith NP, Wong JM, Rajesh V, Sun H, Sharp SA, Rogalski JC, Moravcova R, Cen HH, Manning Fox JE, HI-DAS Consortium, Atlas E, Bruin JE, Mulvihill EE, Verchere CB, Foster LJ, Gloyn AL, Johnson JD, Pepper AR, Lynn FC, Xia J, MacDonald PE. HumanIslets: An integrated platform for human islet data access and analysis. Cell Metabolism, Sep 24:S1550-4131(24)00365-6 (2024). [Full Text]
Gang N, van Allen KA, Willmore WG, Lynn FC, Bruin JE. Crosstalk between the aryl hydrocarbon receptor and hypoxia inducible factor 1α pathways impairs downstream dioxin response in human islet models. BioRxiv (2024). [Full Text]
van Allen K, Gang N, Hoyeck MP, Perera I, Zhang D, Atlas E, Lynn FC, Bruin JE. Characterizing the effects of Dechlorane Plus on β-cells: a comparative study across models and species. Islets, 16:1, 2361996 (2024). [Full Text]
Grieco-St-Pierre L, Bruin JE. Type 2 diabetes is not one-size-fits-all: Subtypes affect complications and treatment options”, The Conversation Canada, April 18 (2024). [Full Text]
Ching AME, Hoyeck MP, Basu L, Merhi R, van Zyl E, Crawley AM, Bruin JE. CYP1A1/1A2 enzymes mediate glucose homeostasis and insulin secretion in mice in a sex-specific manner. BioRxiv (2024). [Full Text]
Hoyeck MP, Ching AME, Basu L, van Allen K, Palaniyandi J, Perera I, Poleo-Giorgani E, Hanson AA, Ghorbani P, Fullerton MD, Bruin JE. The aryl hydrocarbon receptor in β-cells mediates the effects of TCDD on glucose homeostasis in mice. Molecular Metabolism. Feb 2;81:101893 (2024). [Full Text]
2023
Palaniyandi J, Bruin JE, Kumarathasan P, MacPherson S, Borghese MM, Ashley-Martin J. Prenatal exposure to perfluoroalkyl substances and inflammatory biomarker concentrations. Environmental Epidemiology. Jul 25;7(4):e262 (2023). [Full Text]
Hoyeck MP, Merhi RC, Tulloch C, McCormick K, Mohammed Abu Hossain S, Hanson AA, Bruin JE. Fetal and neonatal dioxin exposure causes sex-specific metabolic alterations in mice.Toxicological Sciences. Jun 28;194(1):70-83 (2023).
2022
Basu L, Bruin JE. Why South Asians are at increased risk for diabetes: A complex interplay of genetics, diet and history. The Conversation. Published November 14 (2022).
Hoyeck M*, Matteo G*, MacFarlane EM, Perera I, Bruin JE. Persistent organic pollutants and β-cell toxicity: a comprehensive review. American Journal of Physiology - Endocrinology & Metabolism. May 1;322(5):E383-E413 (2022).
Gang N, Van Allen K, Villeneuve P, MacDonald H, Bruin JE. Sex-specific associations between type 2 diabetes incidence and exposure to dioxin and dioxin-like pollutants: a meta-analysis. Frontiers in Toxicology. Vol 3, Article 685840 (2022).
2021
Matteo G*, Hoyeck M*, Blair H, Zebarth J, Rick KRC, Williams A, Gagné R, Buick JK, Yauk CL, Bruin JE. Prolonged low-dose dioxin exposure impairs metabolic adaptability to high-fat diet feeding in female but not male mice. Endocrinology, 162(6):1-18 (2021). [Full Text]
MacFarlane EM, Bruin JE. Human pluripotent stem cells: a unique tool for toxicity testing in pancreatic progenitor and endocrine cells. Frontiers in Endocrinology. Jan 19;11:604998 (2021). [Full Text]
2020
Hoyeck M, Merhi R, Blair HL, Spencer DC, Payant MA, Alfonso DI, Zhang M, Matteo G, Chee MJ, Bruin JE. Female mice exposed to low doses of dioxin during pregnancy and lactation have increased susceptibility to diet-induced obesity and diabetes. Molecular Metabolism. Dec;42:101104 (2020). [Full Text]
Ibrahim M, MacFarlane EM, Matteo G, Hoyeck MP, Rick KRC, Farokhi S, Copley CM, O'Dwyer S, Bruin JE. Functional cytochrome P450 1A enzymes are induced in mouse and human islets following pollutant exposure. Diabetologia. 63(1):162-178 (2020). [Full Text]
Hoyeck MP, Blair H, Ibrahim M, Solanki S, Elsawy M, Prakash A, Rick KRC, Matteo G, O'Dwyer S, Bruin JE. Long-term metabolic consequences of acute dioxin exposure differ between male and female mice. Scientific Reports. 10(1):1448 (2020).